Abstract: The first global workshop on Smart Specialisation was organised in Seville on 25 September 2018. This workshop has showcased the variety of experiences and interests generated by Smart Specialisation on the five continents and represented a first step towards the creation of an international community of Smart Specialisation. Building on the outcomes and lessons from this event, the present Science for Policy report brings together experiences, policy aspects, challenges and opportunities gravitating around the topic of Smart Specialisation worldwide, and elaborates on the further international potential of the Smart Specialisation concept and approach.